SENONATURALE = Volumetric Breast Augmentation

SENONATURALE is a non-invasive technique in local outpatient anesthesia, which allows you to restore volume to the breast without inserting prostheses, thanks to the injection of a cell suspension formed by adipose tissue cells (adipocytes) and stem cells (present in large numbers in our adipose tissue) of autologous origin (i.e., of the person himself).

SENONATURALE: Who is the ideal candidate

  • The woman with emptied breasts following a pregnancy or after a low-calorie diet
  • The woman who wants to increase the volume of her breasts naturally without inserting foreign bodies and who also wants to sculpt some roundness of the body
  • The woman with asymmetrical breasts
  • The woman who needs breast reconstruction following surgery (after removal of a breast tumor)
  • The woman who has suffered a reduction in the volume of the breasts after breastfeeding
  • The woman who wants to naturally correct the defects caused by breast implant surgery (visibility and palpability of the implants, rippling, breasts that are too far apart, etc.)
  • The woman who is not excessively thin and wants a natural breast augmentation
  • The woman who does not have excessively small breasts.

Example of a NOT ideal candidate. It is impossible to carry out the treatment.

Alternatives for breast augmentation are lipogenetic therapy or the application of breast implants.

Ideal candidate. She was treated with SENONATURALE:

Ideal candidate. She was treated with SENONATURALE:

Ideal candidate. She was treated with SENONATURALE:

SENONATURALE has unique characteristics that include:

  • It does not produce scars. The small holes made with the needle close spontaneously in a short time.
  • Neither the skin, nor the gland, nor the muscle is cut.
  • There will be no pain like prosthetic surgery because the procedure is minimally invasive. Not even after the procedure.
  • The technique is also able to shape the breasts giving a more natural result.

A careful review of the literature accompanied by a series of investigations and laboratory tests on the removal of adipose tissue has allowed us to choose the most suitable method (sampling and purification) that ensures the most significant number of vital fat cells for self-grafting.

Keeping in mind that no one in the world today can ensure 100% vital adipose tissue removal, we took care to obtain a cell suspension that has the maximum possible vitality. The removal of adipose tissue is obtained with manual technique (with a syringe) to avoid the strong depressions of mechanical suction.

The removed fat is immediately “washed” and decanted as these techniques guarantee maximum cell survival. High-speed centrifugation, according to Coleman, was abandoned as it was harmful to adipocytes, as shown by numerous recent studies:

J Plast Reconstr Aesthet Surg. 2010 Aug;63(8):1375-81. doi: 10.1016/j.bjps.2009.07.018. Epub 2009 Aug 12.
Influence of decantation, washing and centrifugation on adipocyte and mesenchymal stem cell content of aspirated adipose tissue: a comparative study
Condé-Green A1, de Amorim NF, Pitanguy I.

Plast Reconstr Surg. 2013 Apr;131(4):873-80. doi: 10.1097/PRS.0b013e31828276e9.
Comparison of three different fat graft preparation methods: gravity separation, centrifugation, and simultaneous washing with filtration in a closed system
Zhu M1, Cohen SR, Hicok KC, Shanahan RK, Strem BM, Yu JC, Arm DM, Fraser JK.

Autologous Fat Grafting – Factors of Influence on the Therapeutic Results
By Regina Khater and Pepa Atanassova

Aesthet Surg J. 2015 Nov;35(8):NP248-60. doi: 10.1093/asj/sjv047. Epub 2015 Apr 28.
Influence of repeated aspiration on viability of fat grafts: a comparative study
Wang R1, Sun J1, Xiong L1, Yang J1.

Comparison of 3 techniques of fat grafting and cell-supplemented lipotransfer in athymic rats: A pilot study
Alexandra Condé-Green, Iwen Wu, Ian Graham, Jemin J. Chae, Cinthia B. Drachenberg, Devinder P. Singh, Luther Holton, Sheri Slezak, Jennifer Elisseeff )

Once the cell suspension rich in stem cells is obtained, through small cutaneous holes, it is injected into the breast following a particular technique to give projection and lift to the breast itself and remodel it. The injection cannulas are small and are the same as those used for face lipofilling.

The cell suspension is rather liquid, and this optimally allows its distribution without exerting any pressure on the acceptor tissue and a natural filling. The injection pressure of the cell suspension is very delicate and very slow to ensure greater vitality to the injected cells (a strong injection pressure damages the adipocytes).

Plast Reconstr Surg. 2014 Mar;133(3):420e-421e. doi: 10.1097/01.prs.0000438465.36711.98.
Reply: The effect of pressure and shear on autologous fat grafting
Lee JH1, McCormack MC, Austen WG Jr.)

How Much Does SENONATURALE Cost?

Traditional breast augmentation with prosthesis costs on average between 6,000 and 9,000 euros. Senonaturale costs less than half and includes the removal of the fat and then a liposculpture of the removal area. Senonaturale starts at 3500 euros. After a thorough examination, a definitive economic measure can be given for the patient’s specific case.

SENONATURALE also allows an immediate and enjoyable result. The breast will remain soft and natural to the touch without the presence of foreign bodies. The benefit of this technique then extends to all the skin tissue of the breast, which thanks to the action of the stem cells contained in the cell suspension, will enjoy greater compactness and brightness; it will also be rejuvenated in its external appearance.

In the before and after image,
there is a volumetric increase and asymmetry correction:

Here, a correction of the prosthetic rippling was performed:

A volumetric increase was performed in the following images:

Another case:senonaturale

SENONATURALE also includes a maintenance program.
Maintenance begins a month / two after the insertion of the cell suspension. It is designed to stimulate the stem cells of the adipose tissue so that they allow a better performance of the injected fat. The first maintenance session is part of the initial treatment; the subsequent sessions are established as a cadence at the control visit and after the first session. People who observe this protocol maintain better results over time. With this protocol, it is possible to avoid re-interventions as it is possible to maintain the graft over time.

SENONATURALE also provides subsequent interventions 8-12 months after the first operation if the person wishes to obtain a further volumetric increase in the breast; this is made possible given the minimally invasive nature of the intervention itself.

Correction of silicone implants approaching the breasts for a more natural look.


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